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Spermatozoa have the highest selenium content in mammalian tissues, and the need for selenium increases at the onset of spermatogenesis ( 2.5 GPX5 Glutathione peroxidase 5 (GPX5), an epididymis-specifically expressed selenium-free antioxidant enzyme, was first isolated and identified in the epididymal tissues of mice ( During epididymis transport, spermatozoa are vulnerable to intracellular and extracellular ROS attacks and rely on antioxidant scavengers synthesized by the epididymis for protection

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